Endocrine Abstracts

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

Introduction.: The diagnosis of GH deficiency (GHD) is based on decreased GH peak in stimulating tests (GHST). Recently, GHD has been re-defined as secondary IGF1 deficiency (IGFD). However, IGF1 may increase during GH therapy in the patients with normal GH peak in GHST, suggesting a diagnosis of non-primary IGFD (npIGFD).The aim of the study was to compare GH therapy effectiveness in children with GHD and with npIGFD (responding to GH administration des...

Introduction: In majority of patients with childhood-onset GH deficiency (GHD), normalisation of GH secretion at the attainment of final height (FH) is observed. However, different criteria for GHD diagnosis may be considered.The aim of the study was to compare the auxological and hormonal data of the patients with persistent and transient GHD, diagnosed according to different criteria.Patients and methods: The analysis comprised 1...

Indications to GH therapy in children with short stature are still a matter of discussion.We compared first-year response to GH therapy in 80 children (62 boys, 18 girls), age 12.7±2.4 years (mean±S.D.) with different disorders of GH secretion. In all the patients nocturnal GH secretion assessed during 3 h after falling asleep was decreased (<10 ng/ml). In 40 children GH deficiency (GHD) was diagnosed on the ground of decreas...

Normal thyroid hormone secretion (or appropriate L-thyroxin substitution) is necessary for the optimal effect GH administration on growing rate. The decrease of free thyroxin (FT4) levels at GH therapy onset was reported in several studies.The aim of our study was to assess the incidence of hypothyroidism (HT) during the initial phase of GH administration in previously euthyroid children with GH deficiency (GHD) and to compare t...

Background: Nocturnal profile of GH secretion is proposed to be a screening diagnostic procedure for GH deficiency (GHD) in short children. Every screening procedure must be characterised by very high sensitivity and good specificity. The data concerning the cut-off level between normal and subnormal nocturnal GH secretion are scarce and non-consistent.The aim of the study was to assess the clinical utility of 2-h nocturnal profile of GH secretion in dia...

Background: Assessment of nocturnal GH secretion is useful tool in diagnosing GH deficiency (GHD) in children. The time period of the evaluation, the number of blood samples, as well as the choice of cut-off value for this examination – are still the matter for discussion.Aim: The aim of the study was to compare the results of 2-h and 6-h assessment of nocturnal GH secretion in children with suspected neurosecretory dysfunction of GH secretion (NSD)...

Fetal undernutrition is at the base of disorders in the differentiation process of pancreatic beta cells. Abnormal insulin activity leads to restriction of fetal growth and to obesity, insulin resistance and diabetes mellitus type 2 (DM2), either in childhood or adulthood. The aim of the study was to assess the incidence of obesity and insulin resistance in prepubertal children, born with body mass too small for their gestational age (SGA).Material and m...

Introduction: Turner syndrome (TS) is a condition caused by structural or numerical abnormalities of X chromosome. Growth deficiency is characteristic for patients with TS, and particular karyotype abnormalities of the X chromosome may be associated with different responsiveness to human GH (hGH) therapy. The aim of the study was to determine the effect of TS karyotype on growth velocity during hGH therapy in TS.Methods: 23 TS patients treated with hGH w...

Introduction: Copeptin can be used as a tool to directly assess serum antidiuretic hormone (ADH) level. A certain pool of ADH are synthesized in hypothalamus, together with corticoliberin (CRH). Then they are released into the pituitary portal circulation, where through the V1bR receptor ADH stimulates adrenocorticotropic cells and ACTH secretion, followed by cortisol and catecholamines production. The stimulus for ADH secretion is, among others, stress. In turn, presynaptic s...